产品介绍：
产品说明
生化/生理作用
UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.
Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1
基本信息
| 经验(实验)分子式 | C43H66N6O8 |
| 分子量 | 795.02 |
产品性质
| 测定 | ≥98% (HPLC) |
| 形式 | lyophilized powder (white) |
| 颜色 | white to off-white |
| 运输 | wet ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
