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Treprostinil

品牌
Sigma-Aldrich
CAS
81846-19-7
货号
SML1531
规格纯度
≥98% (HPLC)
参考价格
2813.53 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Treprostinil is a stable synthetic analog of prostacyclin (prostaglandin PGI2), an IP receptor agonist used clinically for the treatment of pulmonary arterial hypertension. It is a potent vasodilator with antithrombotic, antiproliferative and anti-inflammatory properties.
Treprostinil elicits a longer half-life when compared with iloprost. It mediates inhibition of transforming growth factor-β (TGF-β) and nuclear factor-κB (NF-κB) signaling pathways. Treprostinil effectively reduces right ventricular systolic pressure and inhibits the recruitment of circulating fibrocyte.

基本信息

经验(实验)分子式C23H34O5
分子量390.51
MDL编号MFCD00888847
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D 40 to 50°, c = 0.5 in methanol
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度−20℃
SMILES string[H][C@@]12[C@@](C[C@@H](O)[C@@H]2CC[C@@H](O)CCCCC)([H])CC3=C(OCC(O)=O)C=CC=C3C1
InChI1S/C23H34O5.Na/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25;/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27);/q;+1/p-1/t16-,17-,18+,19-,21+;/m1./s1
InChI keyIQKAWAUTOKVMLE-DQHZMXPSSA-M

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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