位置:首页 > 品牌 > Sigma-Aldrich >

T863

品牌
Sigma-Aldrich
CAS
701232-20-4
货号
SML0539
规格纯度
≥98% (HPLC)
参考价格
1714.02 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:

  • to provide the opportunity to precisely control the DGAT inhibition
  • to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
  • to specifically block neutral lipid synthesis and lipid droplet formation in HT-1080 cells
  • to block lipid droplet (LD) formation

包装

5, 25 mg in glass bottle

生化/生理作用

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

基本信息

经验(实验)分子式C22H26N4O3
分子量394.47
MDL编号MFCD11977270
PubChem化学物质编号329825541
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 15 mg/mL (clear solution)
储存温度2-8℃
SMILES stringCC1(C)Oc2ncnc(N)c2N=C1c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
InChI1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
InChI keyFUIYMYNYUHVDPT-HDJSIYSDSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号