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SHP1 Inhibitor, TPI-1

品牌
Sigma-Aldrich
CAS
79756-69-7
货号
SML3119
规格纯度
≥98% (HPLC)
参考价格
1076.74 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

TPI-1 is an orally bioavailable, noncytotoxic benzoquinone compound that acts as a potent irreversible inhibitor of SHP-1 (Src homology region 2 domain-containing phosphatase 1) catalytic domain (IC50 ~ 40 nM or 0.01 μg/ml) with selectivity over SHP-2 (IC50 ~ 0.1 μg/ml), MKP1 (IC50 > 1 μg/ml) and CD45. TPI-1 potently induces mouse and human primary IFN-g+ cells both in vitro and in vivo. Effectively inhibits B16 melanoma tumors in mice (1 or 3 mg/kg, s.c., daily) and prolong the survival. TPI-1 is shown to be 50-fold more effective than sodium stibogluconate in cell-based assays and may non-specifically react with cysteine residues.

基本信息

经验(实验)分子式C12H6Cl2O2
分子量253.08
MDL编号MFCD00448731

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringO=C1C=CC(C(C2=C(C=CC(Cl)=C2)Cl)=C1)=O

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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