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RRD-251 hydrochloride

品牌
Sigma-Aldrich
CAS
72214-67-6
货号
R7532
规格纯度
≥98% (HPLC)
参考价格
489.22 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

基本信息

经验(实验)分子式C8H8Cl2N2S· HCl
分子量271.59
MDL编号MFCD00035047
PubChem化学物质编号329823647

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to off-white
溶解性DMSO: >10 mg/mL
H2O: >2 mg/mL
储存温度room temp
SMILES stringCl.NC(=N)SCc1ccc(Cl)cc1Cl
InChI1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChI keyCOMNQRICZGJVLE-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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