产品说明
生化/生理作用
Reparixin is a noncompetitive allosteric inhibitor of the inflammatory CXCL8 (IL-8) chemokine receptors CXCR1 and CXCR2 with IC50 values of 1 nM for CXCR1 and 100 nM for CXCR2. It is believed to prevent receptor signaling by locking CXCR1/R2 in an inactive conformation. Reparixin has been studied to prevent ischaemia-reperfusion injury and inflammation and is clinical trials for triple negative breast cancer and to prevent injury occurring after pancreatic islet transplantation.
基本信息
经验(实验)分子式 | C14H21NO3S |
分子量 | 283.39 |
MDL编号 | MFCD18633292 |
产品性质
测定 | ≥98% (HPLC) |
形式 | powder |
旋光性 | [α]/D -80 to -90°, c = 1.0 in ethanol |
颜色 | white to beige |
溶解性 | DMSO: 2 mg/mL, clear |
储存温度 | −20℃ |
InChI | 1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16) |
InChI key | KQDRVXQXKZXMHP-UHFFFAOYSA-N |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |