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RCM-1

品牌
Sigma-Aldrich
CAS
339163-65-4
货号
SML2625
规格纯度
≥98% (HPLC)
参考价格
1174.92 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

RCM-1 is a forkhead box M1 (FOXM1) inhibitor that blocks FOXM1 nuclear localization (IC50 = 720 nM using GFP-FOXM1-expressing U2OS cells) and causes FOXM1 degradation via ubiquitination induction (2.9- and 4.8-fold of basal level in A549 cells with 10 μM or 20 μM RCM-1, respectively) without affecting cellular YAP, FACT140, NF-κB, FOXA2, and FOXJ1 levels. RCM-1 intraperitoneal injection (1.7 mg/kg) in mice downregulates endogenous murine FOXM1 level as well as transgenic human FOXM1 GFP fusion level in vivo, effectively suppressing house dust mite-induced lung inflammation as well as goblet cell metaplasia and airway hyperresponsiveness in response to IL-13.

基本信息

经验(实验)分子式C20H12N2OS4
分子量424.58
MDL编号MFCD00742440

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to very dark orange
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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