位置:首页 > 品牌 > Sigma-Aldrich >

PSB-603

品牌
Sigma-Aldrich
CAS
1092351-10-4
货号
SML1983
规格纯度
≥98% (HPLC)
参考价格
1318.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

PSB-603 is known to modify cellular metabolism and enhance cellular sensitivity for chemotherapy. Thus, PSB-603 is recognized to possess anticancer action, which has been studied in colorectal cancer.
PSB-603 is an adenosine receptor A2b antagonist (IC50 = 1.13 nM against 10 μM A2bR agonist NECA-induced calcium response in Jurkat T cells in the presence of 200 nM A2aR antagonist MSX-2) that targets A2bR with high affinity (KD = 0.403 nM/human, 0.457 nM/rat, 4.09 nM/mouse A2bR; Ki against 0.3 nM [3H]PSB-603 = 0.553 nM/human, 0.355 nM/rat, 0.265 nM/mouse A2bR) and selectivity, exhibiting little affinity toward A1, A2a, or A3 adenosine receptors by competition binding assay (Ki >10 μM against 0.4 nM [3H]DPCPX for human/rat A1R, 1 nM [3H]MSX-2 for human/mouse/rat A2aR, 10 nM [3H]NECA for human/mouse/rat A3R) with the exception of mouse A1R (Ki = 42.2 nM against 0.4 nM [3H]DPCPX).

基本信息

经验(实验)分子式C24H25ClN6O4S
分子量529.01
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to brownish
溶解性DMSO: 2 mg/mL to clear
运输ambient
储存温度2-8℃
SMILES stringO=C(N1CCC)NC2=C(N=C(C3=CC=C(S(=O)(N4CCN(C5=CC=C(Cl)C=C5)CC4)=O)C=C3)N2)C1=O

安全信息

象形图GHS07
警示用语:Warning
危险声明H315
危险分类Skin Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号