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MS436

品牌
Sigma-Aldrich
CAS
1395084-25-9
货号
SML2224
规格纯度
≥98% (HPLC)
参考价格
777.44 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

MS436 is a diazobenzene-based potent BRD4 inhibitor with selective affinity toward the first bromodomain (BrD) of BRD4 (BRD4 BrD1 Ki <85 nM vs. BRD4 BrD2 Ki = 340 nM; IC50 = 460 nM/BRD4 BrD1 vs. 1.29 μM/BRD4 BrD2, 4.95 μM/CBP BrD, 20.29 μM/PCAF BrD). MS436 is a useful tool for probing BRD4-dependent cellular functions, including NF-κB-mediated proinflammatory response in RAW264.7 murine macrophages (IC50 in μM = 4.9/3.8 against LPS-induced IL-6/NO production), human and murine embryonic stem cell (ESC) pluripotency maintenance (10 μM), telomere elongation in mTERT/mTR-overexpressing murine fibroblasts (5 μM), and bioenergetic deficiency caused by mitochondrial complex I (CI)-mutation in human cybrid cells (0.9 μM).

基本信息

经验(实验)分子式C18H17N5O3S
分子量383.42
MDL编号MFCD27992062

产品性质

测定≥98% (HPLC)
形式powder
颜色faint brown to dark red
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringO=S(C(C=C1)=CC=C1/N=N/C2=C(N)C=C(O)C(C)=C2)(NC3=NC=CC=C3)=O

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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