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LY2784544

品牌
Sigma-Aldrich
CAS
1229236-86-5
货号
SML2567
规格纯度
≥98% (HPLC)
参考价格
1225.94 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

LY2784544 is an orally active, ATP-competitive, potent and JAK2-selective janus tyrosine kinase inhibitor (IC50/[ATP] = 2.52 nM/5 μM/JAK2, 19.8 nM/20 μM/JAK1, 48.0 nM/2 μM/JAK3) with little activity toward 79 other kinases. LY2784544 selectively inhibits signaling/proliferation driven by oncogenic JAK2V617F (IC50 = 20/55 nM) over those mediated by wt JAK2 upon IL-3 induction (IC50 = 1183/1309 nM) in Ba/F3 cultures and displays in vivo efficacious in a JAK2V617F-induced murine MPN model (10-80 mg/kg bid po.). LY2784544 is also reported to display Zn-dependent (optimal [Zn+2] = 100 μM) GPR39 agonist activity, but not 11 other GPRs.

基本信息

经验(实验)分子式C23H25ClFN7O
分子量469.94
MDL编号MFCD20482143

产品性质

测定≥98% (HPLC)
形式powder
组成H2O, 0-4 mol/mol (moles per mole of product)
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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