产品说明
一般描述
K145 hydrochloride (3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is an analog of sphingosine.
应用
K145 hydrochloride has been used in the analysis of apoptosis.
包装
5, 25 mg in glass bottle
生化/生理作用
It has the ability to prevent leukemia cell growth in vitro.
K145 (3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is a selective inhibitor of sphingosine kinase-2 (SphK2) and an anticancer agent. K145 selectively inhibited SphK2 in a dose-dependent manner with an IC50 of 4.30 +/- 0.06 μM with no inhibition of SphK1 at concentrations up to 10 μM. K145 significantly suppressed the growth of U937 tumors in nude mice and the growth of JC tumor cells in BALB/c mice.
特点和优势
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
基本信息
| 经验(实验)分子式 | C18H24N2O3S · HCl |
| 分子量 | 384.92 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 20 mg/mL, clear |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
