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IOX1

品牌
Sigma-Aldrich
CAS
5852-78-8
货号
SML0067
规格纯度
≥97% (HPLC)
参考价格
1573.27 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

IOX1 has been used:

  • To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy.
  • In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling.
  • to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.

包装

5, 25 mg in glass bottle

生化/生理作用

IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
IOX1 has an IC50 value as 200nM. IOX1 might be used in the treatment of β-thalassemia by α-globin downregulation.

特点和优势

IOX1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式C10H7NO3
分子量189.17
MDL编号MFCD18417145
PubChem化学物质编号329825131
NACRESNA.77

产品性质

测定≥97% (HPLC)
形式powder
颜色 white to brown
溶解性DMSO: 10 mg/mL, clear
储存温度2-8℃
SMILES stringOC(=O)c1ccc(O)c2ncccc12
InChI1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChI keyJGRPKOGHYBAVMW-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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