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CK-869

品牌
Sigma-Aldrich
CAS
388592-44-7
货号
C9124
规格纯度
≥98% (HPLC)
参考价格
1453.88 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

CK-869 has been used as an Arp2/3 complex inhibitor:

  • to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
  • to induce membrane blebbing in HT1080 fibrosarcoma cells
  • to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

包装

5, 25 mg in glass bottle

生化/生理作用

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.

基本信息

经验(实验)分子式C17H16BrNO3S
分子量394.28
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to light gray
溶解性DMSO: 10 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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