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BD 1063 dihydrochloride

品牌
Sigma-Aldrich
CAS
206996-13-6
货号
SML0276
规格纯度
≥98% (HPLC)
参考价格
1362.16 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:

  • to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells
  • in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)
  • to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells

包装

5, 25 mg in glass bottle

生化/生理作用

BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.

其他说明

air sensitive

基本信息

经验(实验)分子式C13H18Cl2N2 · 2HCl
分子量346.12
MDL编号MFCD00792740
PubChem化学物质编号329825284
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to beige
溶解性H2O: >15 mg/mL
储存温度room temp
SMILES stringCl.Cl.CN1CCN(CC1)CCc2ccc(Cl)c(Cl)c2
InChI1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H
InChI keyNXFDBTLQOARIMH-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H319
预防措施声明P305 + P351 + P338
危险分类Eye Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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