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BAY-6035

品牌
Sigma-Aldrich
货号
SML2325
规格纯度
≥98% (HPLC)
参考价格
1050.14 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

BAY-6035 is a substrate-competitive, potent and selective SMYD3 inhibitor (IC50 = 88 nM by cell-free MEKK2 peptide methylation; IC50 = 70 nM against cellular MEKK2 methylation) with >100-fold selectivity over other histone methyltransferases. BAY-211 is a structural analog and the recommended inactive control (IC50 = 23 μM by cell-free MEKK2 peptide methylation) for BAY-6035. For characterization details of BAY-6035, please visit the BAY-6035 probe summary on the Structural Genomics Consortium (SGC) website.

BAY-444 is the negative control for the active probe, BAY-6035. To request a sample of the negative control from the SGC, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

BAY-6035 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

基本信息

经验(实验)分子式C22H28N4O3
分子量396.48
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度−20℃
SMILES stringO=C1C[C@H](C)N(C(N2CC(C3)C3C2)=O)C4=CC=C(C(NCCC5CC5)=O)C=C4N1

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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