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BAY 36-7620

品牌
Sigma-Aldrich
CAS
232605-26-4
货号
SML2917
规格纯度
≥98% (HPLC)
参考价格
1272.2 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

BAY36-7620 is a non-competitive, potent and selective metabotropic glutamate mGlu1 receptor (mGluR1) antagonist (IC50 = 160 nM against 0.1 μM (EC50) Glu-stimulated IP) with inverse agonist activity (IC50 = 380 nM with 36-44% basal IP inhibition at 10 μM). BAY36-7620 exhibits neuroprotective (0.01 and 0.03 mg/kg/h, iv. infusion during 4h post acute subdural hematoma induction in rats; triple 0.03-3 mg/kg bolus iv. 0, 2 & 4 h post middle cerebral artery occlusion in rats) and anticonvulsive (MED = 10 mg/kg, iv. immediately after pentylenetetrazole-induced convulsions in mice) efficacy in vivo.

基本信息

经验(实验)分子式C19H18O2
分子量278.35
MDL编号MFCD03700725

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D -43 to -35°, c = 0.5 in chloroform-d
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringC=C1C[C@@](CC2=CC3=C(C=C2)C=CC=C3)(C(OC4)=O)[C@]4([H])C1

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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