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Aramchol

3β-arachidyl-amido, 7α-12α-dihydroxy, 5β-cholan-24-oic acid

品牌
Sigma-Aldrich
CAS
246529-22-6
货号
SML2352
规格纯度
≥98% (HPLC)
参考价格
838.49 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer that has the potential to prevent and dissolves cholesterol gallstones in inbred mice and in human gallbladder bile ex vivo.
Aramchol is a bile salt fatty acid conjugate (BAFAC) of arachidic acid and cholic acid. It has been shown to reduce liver fat by a dual mechanism of action. It inhibits the activity of liver stearoyl coenzyme A desaturase 1 (SCD1), decreasing the synthesis of fatty acids. In addition, it activates cholesterol efflux by stimulating the adenosine triphosphate–binding cassette transporter A1 (ABCA1). Aramchol has been investigated for treatment for nonalcoholic steatohepatitis, or NASH.

基本信息

经验(实验)分子式C44H79NO5
分子量702.10
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringCCCCCCCCCCCCCCCCCCCC(N[C@@H]1C[C@](C[C@@H](O)[C@]2([H])[C@]3([H])C[C@H](O)[C@@]4(C)[C@@]2([H])CC[C@]4([H])[C@@H](CCC(O)=O)C)([H])[C@]3(C)CC1)=O

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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