产品介绍：
产品说明
生化/生理作用
7ACC2 is a monocarboxylate transporters MCT1 & MCT4 (SLC16A1 & SLC16A3) inhibitor that affects lactate uptake-dependent cancer growth in cultures (uptake/proliferation IC50 = 59/220 nM; MCT1/4-expressing SiHA cervix cancer in the absence of glucose) and in vivo (3 mg/kg/day i.p.; SiHa, HCT116, MCF-7 in mice), without affecting lactate efflux or the survival of highly glycolytic HL-60 (MCT1) or MDA-MB231 (MCT4) cancer cells. Unlike the MCT1/2 inhibitor AR-C155858, 7ACC2 does not block MCT1-mediated uptake of the anti-cancer drug 3-bromopyruvate (3-BP).
基本信息
| 经验(实验)分子式 | C18H15NO4 |
| 分子量 | 309.32 |
| MDL编号 | MFCD28167835 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | O=C(O)C1=CC2=C(C=C(C=C2)N(C)CC3=CC=CC=C3)OC1=O |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
