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MJ33 lithium salt

MJ33 锂盐

品牌
Sigma-Aldrich
CAS
199106-13-3
货号
M3315
规格纯度
powder, ≥90% (NMR)
参考价格
2684.1 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor:

  • to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates
  • to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia
  • to study its potential use as a therapeutic agent

包装

5 mg in glass bottle

生化/生理作用

MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate.
Novel, active site directed, specific, competitive and reversible inhibitor of phospholipase A2 (PLA2).

基本信息

经验(实验)分子式C22H43F3O6PLi
分子量498.48
MDL编号MFCD03787978
PubChem化学物质编号24278549
NACRESNA.77

产品性质

质量水平100
测定≥90% (NMR)
形式powder
颜色 white to beige
溶解性H2O: ≥5 mg/mL (warmed at 60 ℃)
储存温度2-8℃
SMILES stringCCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(OC)([O-])=O.[Li+]
InChI1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1
InChI keyGDLMLQJISATCEL-UHFFFAOYSA-M

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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