产品介绍：
产品说明
应用
MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor:
- to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates
- to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia
- to study its potential use as a therapeutic agent
包装
5 mg in glass bottle
生化/生理作用
MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate.
Novel, active site directed, specific, competitive and reversible inhibitor of phospholipase A2 (PLA2).
基本信息
| 经验(实验)分子式 | C22H43F3O6PLi |
| 分子量 | 498.48 |
| MDL编号 | MFCD03787978 |
| PubChem化学物质编号 | 24278549 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥90% (NMR) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | H2O: ≥5 mg/mL (warmed at 60 ℃) |
| 储存温度 | 2-8℃ |
| SMILES string | CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(OC)([O-])=O.[Li+] |
| InChI | 1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1 |
| InChI key | GDLMLQJISATCEL-UHFFFAOYSA-M |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
