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N,N-Dimethylmethyleneiminium chloride

N , N -二甲基亚甲蓝

品牌
Sigma-Aldrich
CAS
30354-18-8
货号
40766
规格纯度
≥95.0% (AT)
参考价格
1187.51 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

N,N-Dimethylmethyleneiminium chloride (Böhme′s salt) is a dimethylaminomethylating agent that can be used as one of the key reagents in the following applications:

  • Electrophilic aminomethylation of aldehydes and ketones to synthesize corresponding Mannich products, also known as Mannich reaction.
  • Preparation of dihydronaphthyridinones as HIV-1 integrase inhibitors.
  • Preparation of cyanotetrahydrooxo-β-carbolines via cyclocondensation of cyanomethyl indole-2-carboxylate with ammonia.
  • Asymmetric synthesis of phalarine via stereospecific Pictet-Spengler cyclocondensation and traceless chirality transfer from L-tryptophan.
  • Synthesis of functionalized diarylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX).
  • Synthesis of (±)-phalarine with the rearrangement of an azaspiroindolenine and Gassman oxindole preparation as key steps.


Reacant for:
Preparation of dihydronaphthyridinones as HIV-1 integrase inhibitors
Mannich reactions
Preparation of cyanotetrahydrooxo-ß-carbolines via cyclocondensation reactions
Asymmetric synthesis of phalarine via stereospecific Pictet-Spengler cyclocondensation and traceless chirality transfer from L-tryptophan
Synthesis of functionalized diarylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX)
Synthesis of (±)-phalarine with the rearrangement of an azaspiroindolenine and Gassman oxindole preparation as key steps

包装

5, 25 g in glass bottle

其他说明

供直接使用的"Mannich 试剂";与传统的"Mannich 反应"相比,可在更短时间内生成产量和纯度更高的产物;与三氟甲磺酸三甲基硅酯原位制备反应性三氟甲磺酸盐

基本信息

线性分子式CH2=N+(CH3)2Cl-
分子量93.56
Beilstein505955
EC 号250-142-4
MDL编号MFCD00011809
PubChem化学物质编号57650016
NACRESNA.22

产品性质

质量水平100
测定≥95.0% (AT)
reaction suitabilityreaction type: C-C Bond Formation
mp146-148 ℃ (lit.)
SMILES string[Cl-].C[N+](C)=C
InChI1S/C3H8N.ClH/c1-4(2)3;/h1H2,2-3H3;1H/q+1;/p-1
InChI keyZJTROANVDZIEGB-UHFFFAOYSA-M

安全信息

象形图GHS02GHS07
警示用语:Warning
危险声明H228 - H315 - H319 - H335
预防措施声明P210 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码4.1B - Flammable solid hazardous materials
WGKWGK 3
闪点(F)179.6 °F - closed cup
闪点(C)82 ℃ - closed cup
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

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