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Lipopolysaccharides from Akkermansia muciniphila

品牌
Sigma-Aldrich
货号
SBR00027
规格纯度
Purified by phenol extraction
参考价格
2570.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).,
Akkermansia muciniphila (A. muciniphila) is a gram negative, anaerobic, non motile, non spore forming and oval shaped bacterium. A. muciniphila inhabits the gastrointestinal tracts of more than 90% of adults and constitutes 1-4% of the fecal microbiota. A. muciniphila levels were suggested to serve as biomarker for a healthy intestine.
A. muciniphila degrades mucus and utilizes it as a carbon/nitrogen source. Consequently, the host produces additional mucus while the bacterium produces oligosaccharides and Short Chain Fatty Acids (SCFAs) that can be utilized by the host and trigger the immune system. An additional protective effect of the SCFA is stimulation of mucus-associated microbiota growth, that serves as a barrier against penetration of pathogens to intestinal cells.,
A. muciniphila was crowned as the next-generation beneficial microbe. Several reports have indicated that A. muciniphila affects glucose metabolism, lipid metabolism, and intestinal immunity. In addition, decreasing levels of A. muciniphila are related to the development of some diseases such as metabolic disorders and inflammatory diseases (obesity, type 2 diabetes, inflammatory bowel disease (IBD), autism and atopy. Weir et al. found a correlation between low level of A. muciniphila and colorectal cancer. Shigemetzu Y et al. found that A. muciniphila acts as a regulator of the response to PD-1 blockade which is used for anti-cancer immunotherapy. A. muciniphila induce dendritic cells to secrete IL-12, that is a critical component of the anti-cancer effect of PD-1 blockade.
LPSs from A. muciniphila stimulate NF-κB dependent secreted embryonic cell alkaline phosphatase (SEAP) production via TLR4. In addition, it induces IL-8, IL-6 and minimal amounts of IL-10 and TNF-α in peripheral blood mononuclear cells (PBMCs). A. muciniphila stimulation of IL-8 production by enterocytes was shown to be significantly (100 fold) lower than E. coli stimulation. Low proinflammatory activity keep the mucosa-associated immune system alerted at an appropriate level for generation of mucosal homeostasis.

产品性质

质量水平100
形式lyophilized powder
储存温度2-8℃

安全信息

象形图GHS06
警示用语:Danger
危险声明H300
预防措施声明P301 + P310 + P330
危险分类Acute Tox. 2 Oral
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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