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LRH-1 human

品牌
Sigma-Aldrich
货号
SRP2070
规格纯度
recombinant, expressed in insect cells, ≥70% (SDS-PAGE)
参考价格
7018.5 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

LRH-1 or HB1F for human B1-binding factor belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors and is closely related to steroidogenic factor-1. LRH1 contains a DNA-binding domain with 2 zinc finger motifs, an FTZ-F1 box, and a ligand-binding domain. Cholesterol 7-α-hydroxylase is the first and rate-limiting enzyme in a pathway through which cholesterol is metabolized to bile acids. Elevated promoter-specific repressor protein (SHP) inactivates LRH1 by forming a heterodimeric complex that leads to promoter-specific repression of both CYP7A1 and SHP. These results revealed an elaborate autoregulatory cascade mediated by nuclear receptors for the maintenance of hepatic cholesterol catabolism. LRH1 specifically binds and activates viral hepatitis B enhancer II, an essential element for the liver-specific regulation of hepatitis B virus gene expression. CPF is a key regulator of human CYP7A gene expression in the liver. SHP1 represses expression of CYP7A1 by inhibiting the activity of LRH1 which regulates CYP7A1 expression positively. This bile acid-activated regulatory cascade provides a molecular basis for the coordinate suppression of CYP7A1 and other genes involved in bile acid biosynthesis.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in insect cells
测定≥70% (SDS-PAGE)
形式frozen liquid
分子量 ~62.6 kDa
包装pkg of 5 μg
浓度50 μg/mL
颜色clear colorless
NCBI登记号NM_205860
UniProt登记号O00482
运输dry ice
储存温度−70℃
Gene Informationhuman ... NR5A2(2494)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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