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ErbB4/HER4 HIS tag human

品牌
Sigma-Aldrich
货号
SRP6594
规格纯度
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
参考价格
3896.85 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Akt3 or Protein Kinase B γ (PKB) is a serine/threonine kinase that is a member of the Akt family. In mammals, the Akt family comprises of three highly homologous members known as Akt1 (PKB), Akt2 (PKB), and Akt 3. Akt 3 like the other family members is activated in cells exposed to diverse stimuli such as hormones, growth factors, and extracellular matrix components. The activation mechanism remains to be fully characterized but occurs downstream of phosphoinositide 3-kinase (PI3K). PI3K generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of Akt family members to the plasma membrane where they are phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1) and phosphoinositide-dependent kinase-2 (PDK-2 possibly ILK). Akt 3 like the other family members phosphorylates and regulates the function of many cellular proteins involved in processes that include cellular metabolism, survival/apoptosis, and proliferation. Recent evidence indicates that Akt 3 is frequently overexpressed in many types of human cancers including breast and prostate. Although the mechanisms have not yet been fully characterized, increased expression and activation of Akt is believed to promote cell proliferation and survival thereby contributing to cancer progression.

外形

Sterile filtered white lyophilized (freeze-dried) powder. The protein was lyophilized from 50mM Sodium Chloride solution.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
标签His tagged
测定≥95% (SDS-PAGE)
形式lyophilized
分子量 5.8 kDa
包装pkg of 5 μg
UniProt登记号P01308
运输dry ice
储存温度−70℃
Gene Informationhuman ... ERBB4(2066)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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