Dimethyl Sphingosine (d18:1)

产品说明

一般描述

Dimethyl Sphingosine (d18:1), also called as N,N-Dimethyl-d-erythro-sphingosine (DMS), is a natural sphingolipid metabolite. It is found in various tissues.

应用

Dimethyl Sphingosine (d18:1) may be used:

• to investigate D-erythro-N,N-dimethylsphingosine (DMS)-induced cell death in U937 cells to understand its molecular mechanism
• to study its effects on intracellular Ca²⁺ concentration, pH and glutamate uptake in human 1321N1 astrocytes
• in substrate specificity studies of sphingosine methyltransferase activity in rat kidney homogenate

Dimethyl sphingosine (d18:1) has been used as an inhibitor of sphingosine kinase.

生化/生理作用

D-erythro-N,N-dimethylsphingosine (DMS) prevents the activity of sphingosine kinase and protein kinase C. It modulates cellular activities. DMS exhibits anti-cancer and apoptotic properties. It is involved in the augmentation of epidermal growth factor receptor (EGFR) and inhibition of src kinase. DMS functions as a potential therapeutic for Chagas disease cardiomyopathy through its anti-parasitic and immunomodulatory properties.
D-erythro-N,N-dimethylsphingosine (DMS) has an ability to inhibit the activity of sphingosine kinase. It also helps to study the role of sphingosine 1-phosphate (SPP) as an intracellular second messenger. DMS exhibits anti-parasitic and immunomodulatory activities. It acts as a potential therapeutic for chronic Chagas disease cardiomyopathy.

包装

5 mL Clear Glass Sealed Ampule (860496O-5mg)

基本信息

经验(实验)分子式	C20H41NO2
分子量	327.55
NACRES	NA.25

产品性质

包装	pkg of 1 × 5 mg (860496O-5mg)
manufacturer/tradename	Avanti Polar Lipids 860496O
运输	dry ice
储存温度	−20℃
SMILES string	OC[C@@](N(C)C)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI	1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
InChI key	YRXOQXUDKDCXME-YIVRLKKSSA-N

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable