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BRG1-mt, K798R human

品牌
Sigma-Aldrich
货号
SRP2037
规格纯度
recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
参考价格
6089.88 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The SMARCA4 (SWI/SNF (SWItch/sucrose non-fermentable) related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) gene is mapped to human chromosome 19p13.2. The protein encoded by the SMARCA4 gene is an ATPases transcription activator with multisubunits (12-15).

生化/生理作用

BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes and is implicated in multiple functions through its interaction with different proteins, including the tumor suppressor protein pRb, serine-threonine kinase LKB1, and other transcription factors. Mutation of lysine to arginine at position 798 in the DNA-dependent ATPase domain of BRG1 a) failed to restore normal growth to swi2- cells, b) reduced its ability to repress c-fos transcription, and c) reduced CIITA (class II transactivator) induction and enhanced the rate of induction of the interferon-g-responsive GBP-1 gene.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in insect cells
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~185 kDa
包装pkg of 5 μg
储存条件avoid repeated freeze/thaw cycles
浓度300  μg/mL
颜色 clear
colorless
NCBI登记号NM_003072
UniProt登记号P51532
运输dry ice
储存温度−70℃
Gene Informationhuman ... SMARCA4(6597)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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