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Anti-Phospho-Stat1 (Tyr701) Antibody, clone 5C9.2

品牌
Sigma-Aldrich
货号
05-1064
规格纯度
clone 5C9.2, from mouse
参考价格
5520.38 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

STATs (Signal-Transducing Activators of Transcription) are the principle substrates of JAK kinases, and mediators of cytokine signaling. STAT proteins have SH2 domains, and once phosphorylated by JAK kinases, STATs dimerize in a head-to-tail fashion, through their SH2 domains. STAT1 is a critical mediator of IFN signaling, STAT4 is specific to IL-12, STAT6 is activated primarily by IL-4 and IL-13, while STAT5 A and B appear to be most important to the function of growth hormone and prolactin. STAT3 is involved in multiple signaling pathways, and mice deficient in it are not viable. In addition to tyrosine phosphorylation, many STAT proteins are targets of Ser/Thr kinases, and those phosphorylation events potentiate STAT-induced transcription. The phosphorylation state of STATs can be monitored by phosphorylation state-specific antibodies.

特异性

This antibody recognizes phosphorylated STAT1 at tyrosine 701.

免疫原

Epitope: Phosphorylated Tyr701
KLH-conjugated linear peptide corresponding to the region around phosphorylated tyrosine 701.

应用

Research Sub Category
Transcription Factors
Anti-Phospho-Stat1 (Tyr701) Antibody, clone 5C9.2 detects level of Phospho-Stat1 (Tyr701) & has been published & validated for use in WB.
Research Category
Epigenetics & Nuclear Function

质量

Routinely evaluated by western blot on EGF treated and untreated A431 cell lysate.
Western Blot Analysis: 0.5-2 µg/mL of this lot was used to detect STAT1 phosphorylated at Tyr701 in EGF treated and untreated A431 cell lysates.

目标描述

88-92 kDa

外形

Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS and 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8ºC from date of receipt.

分析说明

Control
EGF treated and untreated A431 cell lysates, PDGF treated and untreated NIH/3T3 cell lysates, pervanadate treated and untreated PC12 cell lysates.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆5C9.2, monoclonal
species reactivitymouse, rat, human
technique(s)western blot: suitable
同位素/亚型IgG1κ
NCBI登记号NP_009330
UniProt登记号P42224
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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