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SRC1 (627-786), biotin, untagged human

品牌
Sigma-Aldrich
货号
SRP2066
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
参考价格
6262.52 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Steroid receptor coactivator 1 (SRC1) is also known as nuclear receptor coactivator 1 (NCOA1). The gene encoding it is localized on human chromosome 2p23.3.

生化/生理作用

Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 has been shown to be over expressed in some cancers. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptorsand has been previously used in assays detecting ligand-dependent receptor-cofactor interactions. This protein does not contain a His tag and will be useful for assays where a native untagged protein is desired. Lane 1 corresponds to 6His-tagged and biotinylated SRC-RID; Lane 2 corresponds to biotinylated SRC-RID without 6His tag.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~19.8 kDa
包装pkg of 5 μg
储存条件avoid repeated freeze/thaw cycles
颜色clear colorless
NCBI登记号NM_003743
UniProt登记号Q15788
运输dry ice
储存温度−70℃
Gene Informationhuman ... NCOA1(8648)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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