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MAPKAPK2 human

品牌
Sigma-Aldrich
货号
M0195
规格纯度
recombinant, expressed in HEK 293 cells, ≥60 units/mg protein, buffered aqueous glycerol solution
参考价格
8847.2 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

MAPKAPK2 is a serine/threonine protein kinase activated by the p38 MAP kinase in response to various signals including mitogenic and stress stimuli. MAPKAPK2 is distinguished from the RSK family of ribosomal protein S6 kinases (also termed MAPKAPK1), which are activated by the MAP kinases, ERK1, and ERK2 based on its substrate specificity and amino acid sequence. Upon activation, p38 MAP kinase activates the downstream MAPKAPK2 by phosphorylation of the threonine residue in the Pro-Thr motif in response to heat shock or mitogenic stimuli. Activated MAPKAPK2 phosphorylates the small heat shock protein HSP25/HSP27, both in vitro and in vivo, at serine residues. Thus, HSP25/HSP27 seems to be the physiological substrate of MAPKAPK2.

单位定义

One unit will incorporate 1.0 nmole of phosphate into HSP 25 per minute at 30 ℃ at pH 7.4.

外形

Solution in 50 mM Tris-HCl, pH 7.4, 100 mM NaCl, 0.05 mM EDTA, 2 mM DTT, and 10% glycerol.

基本信息

MDL编号MFCD04974881
NACRESNA.32

产品性质

重组expressed in HEK 293 cells
质量水平100
形式buffered aqueous glycerol solution
specific activity≥60 units/mg protein
分子量 45-60 kDa
UniProt登记号P49137
运输dry ice
储存温度−70℃
Gene Informationhuman ... MAPKAPK2(9261)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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