产品说明
Amino Acid Sequence
Ac-Ala-Glu-Val-Asp-al
一般描述
Currently, there are 13 caspases recognized in mammals. Caspases are classified as initiators and effectors. Caspase 8 belongs to the class of initiators. It possesses a prodomain at the terminal and contains the death effector domain which serves as protein-protein interaction motif for caspase 8. With respect to substrate specificity, caspase 8 is classified as a member of group III. It specifically recognizes the (I/L/V) EXD sequence on the substrate.
应用
Caspase Inhibitor has been used to study the specificity of the CIL-1 (desglucoanagalloside B) interaction with the caspase 3/7 system.
生化/生理作用
The peptide Ac-Ala-Glu-Val-Asp-al, or Ac-AEVD-CHO, is an inhibitor of Group III caspases. It acts upon caspases-6, 8, 9, and 10, with particular effectiveness on caspase-6 and caspase-8. The use of Ac-AEVD-CHO in several apotosis studies has been reported.
基本信息
| 经验(实验)分子式 | C19H30N4O9 |
| 分子量 | 458.46 |
| NACRES | NA.32 |
产品性质
| 测定 | ≥95% (HPLC) |
| 形式 | lyophilized |
| 组成 | Peptide Content, ≥80% |
| 储存条件 | protect from light |
| 储存温度 | −20℃ |
| Gene Information | human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
