产品说明
一般描述
Gemin-2 (also known as SIP1 or SMN interacting protein1) is a part of the SMN complex. The SMN complex plays a role in RNA metabolism and in splicing regulation. As part of the SMN complex Gemin-2 interacts directly with Gemin-5 in a heteromeric complex that includes Gemin-3, Gemin-4, Gemin-6. This macromolecular complex (SMN complex) mediates assembly of spliceosomal snRNA complexes containing U1 and U5.
特异性
Antibody recognizes Gemin-2.
免疫原
His-tagged recombinant protein corresponding to human Gemin-2.
应用
Research Sub Category
RNA Metabolism & Binding Proteins
Neurodegenerative Diseases
Anti-Gemin2 Antibody, clone 2E17 is a Mouse Monoclonal Antibody for detection of Gemin2 also known as SMN interacting protein 1-delta & has been validated in WB, ICC, ELISA & IP.
Research Category
Epigenetics & Nuclear Function
Immunocytochemistry:
Cited in Battle, D.J., et. al (2007). J. Biol. Chem. 282: 27953 - 27959 and Zhang, Z., et. al (2008). Cell, 133:85-600. using a representative lot.
ELISA:
Cited in Zhang, Z., et. al (2008). Cell, 133:85-600.
Immunoprecipitation:
Cited in Battle, D.J., et. al(2007). J. Biol. Chem. 282: 27953 - 27959 using a representative lot.
质量
Evaluated by Western Blotting in HeLa cell lysates.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Gemin-2 in HeLa cell lysates.
目标描述
32 kDa Calculated
外形
Format: Purified
Purified mouse IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide
Protein G Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
HeLa cell lysates.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 抗体形式 | purified antibody |
| antibody product type | primary antibodies |
| 克隆 | 2E17, monoclonal |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology) |
| technique(s) | ELISA: suitable immunocytochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| 同位素/亚型 | IgG1κ |
| NCBI登记号 | NM_001009182.1 |
| UniProt登记号 | O14893 |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
