IKK-2 Inhibitor V-CAS 978-62-1-Calbiochem

产品说明

一般描述

A cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC₅₀ ~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC₅₀<1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKA_y mice by regulating adiponectin release.
A cell-permeable IKK-2 inhibitor that selectively blocks IκBα phosphorylation (IC₅₀ ~250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Reported to suppress neoplastic proliferation of mast cells with constitutively activated c-kit receptor. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC₅₀<1 µM) in cardiomyocytes, and ameliorate insulin resistance in diabetic KKA_y mice by regulating adiponectin release.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
IKK-2
Product does not compete with ATP.
Reversible: no
Target IC₅₀: ~ 250 nM blocking IκBα phosphorylation

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun.323, 242.
Onai, Y., et al. 2004. Cardiovasc. Res.63, 51.
Tanaka, A., et al. 2004. Blood105, 2324.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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