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Cilostamide

环己喹酰胺

品牌
Sigma-Aldrich
CAS
68550-75-4
货号
C7971
规格纯度
phosphodiesterase inhibitor
参考价格
5452.52 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.
PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.

基本信息

经验(实验)分子式C20H26N2O3
分子量342.43
MDL编号MFCD00673958
PubChem化学物质编号24278337
NACRESNA.77

产品性质

质量水平100
测定≥97% (HPLC)
形式powder
溶解性DMSO: 20 mg/mL, clear, colorless to faintly yellow
SMILES stringCN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
InChI1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChI keyUIAYVIIHMORPSJ-UHFFFAOYSA-N
Gene Informationhuman ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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