产品说明
一般描述
Granzyme B (GzmB) is a serine protease which is stored in granules of activated cytotoxic T cells and NK cells. GZMB codes for granzyme B.
生化/生理作用
Granzyme B is considered as the marker of activated CTLs (cytotoxic T-cells), which mediates target-cell apoptosis. It induces apoptosis in caspase-dependent and caspase-independent manner. After contact with target cells, granzyme B is directionally exocytosed, and then enters the target cell with assistance from perforin. Granzyme B specifically cleaves after Asp residues, and particularly processes and activates various pro-caspases. This induces apoptosis in the target cell.
单位定义
One unit is defined as the amount of enzyme that hydrolyzes 1 pmol/min of IETD-AFC per min at 37℃ in 50 mM HEPES, pH 7.5 containing 10 mM CaCl2.
外形
Lyophilized powder, containing HEPES buffer (original solution at pH 7.5)
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in insect cells |
| 测定 | ≥90% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | >0.004 units/mg |
| specific activity | ≥40 units/μg |
| 包装 | pkg of 5 μg |
| UniProt登记号 | P10144 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GZMB(3002) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
