位置:首页 > 品牌 > Sigma-Aldrich >

Granulocyte-Macrophage Colony-Stimulating Factor from rat

品牌
Sigma-Aldrich
货号
G0792
规格纯度
GM-CSF, recombinant, expressed in E. coli
参考价格
6694.12 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Four distinct colony-stimulating factors (CSFs) promoting survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte-macrophage-CSF (GM-CSF), granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF), and interleukin-3 (IL-3, Multi-CSF). GM-CSF is a multipotential growth factor, stimulating proliferation of progenitor cells from more than one hematopoietic lineage (granulocyte, macrophage, and eosinophil). GM-CSF stimulates colony formation from pluripotent progenitor cells at extremely low concentrations and is an essential survival and proliferative factor for hematopoietic progenitor cells in all divisions up to maturity. GM-CSF induces myeloid progenitor cells from bone marrow to form colonies containing macrophages and granulocytes in a semisolid media. It is produced by various cell types (activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts) in response to cytokine and inflammatory stimuli. In addition to granulocyte-macrophage progenitors, GMCSF is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF can induce nonhematopoietic cells such as endothelial cells to migrate and proliferate. It also stimulates the proliferation of tumor cell lines, including osteogenic sarcoma, carcinoma, and adenocarcinoma cell lines. GM-CSF exerts its biological effects through binding to specific cell surface receptors. The high affinity GM-CSF receptors contain a GM-CSF-specific α?chain and a common α ?chain.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

制备说明

Recombinant Rat Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is produced from a DNA sequence encoding mature rat GM-CSF. This recombinant protein is a mixture of two rat GM-CSFs, the 127 amino acid form and the 128 amino acid methionyl form. Mature rat GM-CSF has a calculated mass of 14.7 kDa. GM-CSF, an acidic glycoprotein, is species-specific.

分析说明

The biological activity is measured by its ability to induce proliferation of the factor-dependent mouse cell line, DA3.

基本信息

MDL编号MFCD01868356
NACRESNA.77

产品性质

质量水平100
生物来源rat
重组expressed in E. coli
测定>97% (SDS-PAGE)
形式lyophilized powder
效能0.03-0.1 ng/mL
质量endotoxin tested
分子量 14.7 kDa
包装pkg of 5X5 μg
pkg of 5 μg
储存条件avoid repeated freeze/thaw cycles
杂质<1 EU/μg
UniProt登记号P48750
储存温度−20℃
Gene Informationrat ... CSF2(116630), Csf2(116630)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号