TOFA-CAS 54857-86-2-Calbiochem

产品说明

一般描述

A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC₅₀ = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.
A cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC₅₀ = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effects of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Acetyl-CoA carboxylase (ACC)
Target IC₅₀: 4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7
Reversible: yes
Cell permeable: yes
Product competes with ATP.

警告

Toxicity: Carcinogenic / Teratogenic (D)

制备说明

Slight warming and sonication may be required for complete solubilization in ethanol.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Landree, L.E., et al. 2004. J. Biol. Chem.279, 3817.
Zhou, W., et al. 2003. Cancer Res.63, 7330.
Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA100, 12624.
Pizer, E.S., et al. 2000. Cancer Res.60, 213.
Arbeeny, C.M., et al. 1992. J. Lipid Res.33, 843.
Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res.25, 831.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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