产品说明
一般描述
A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
包装
5 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Bruno, O., et al. 2011. Br. J. Pharmacol.in press.
Bruno, O., et al. 2009. J. Med. Chem.52, 6546.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C21H30N2O5 |
| 分子量 | 390.47 |
| MDL编号 | MFCD28053503 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | semisolid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | pale yellow |
| 溶解性 | DMSO: 100 mg/mL, clear, colorless |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| SMILES string | COC1=C(OC2CCCC2)C=C(/C([H])=N/OCC(N3CC(C)OC(C)C3)=O)C=C1 |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
