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Integrin αvβ3 Antagonist, P11-Calbiochem

Integrin αvβ3 Antagonist, P11-Calbiochem

品牌
Sigma-Aldrich
货号
407272
规格纯度
The Integrin αvβ3 Antagonist, P11 controls the biological activity of Integrin αvβ3.
参考价格
2340.22 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

Supplied as a trifluoracetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Bang, J., et al. 2011. Mol Cell Proteomics10, M110.
Choi, Y., et al. 2010. Proteomics10, 72.
Lee, Y., et al. 2004. J. Biomol. Screen.9, 687.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C30H51N12O93 · 3C2HF3O2
分子量2409.82

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性water: 100 mg/mL
运输wet ice
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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