产品说明
一般描述
Cell permeable. Potently inhibits Aβ42 production (IC50 = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.
A potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ42 (IC50 = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APPSα, but no change in secreted APPSβ, indicating a specific inhibition of γ-secretase activity.
包装
5 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Target IC50: 1.8 µM against Aβ42 production
Product does not compete with ATP.
Reversible: no
Primary Target
Aβ₄₂ production
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Rishton, G.M., et al. 2000. J. Med. Chem.43, 2297.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C16H22FNO2S |
| 分子量 | 311.41 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze |
| 颜色 | white |
| 溶解性 | DMSO: 200 mg/mL |
| 运输 | ambient |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
