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TrkB Antagonist, ANA-12-CAS 219766-25-3-Calbiochem

品牌
Sigma-Aldrich
CAS
219766-25-3
货号
5.06304
包装型号
规格纯度
参考价格
3162 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor. Binds to the high affinity site on the extracellular domain of TrkB in a dose-dependent manner (Kd = 10 nM) exhibiting much reduced binding to the low affinity site (Kd =12 µM) indicating that it does not compete with BDNF for the same binding site. Does not affect TrkA or TrkC receptors. Shown to permeate the blood-brain barrier, however, its antagonistic effects are not uniform throughout the brain. Does not affect the survivability of neurons. Reduces anxiety and depression related behavior in mice.

生化/生理作用

Primary Target
TrkB

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Cazorla, M., et al. 2011. J. Clin. Invest.121,1846.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C22H21N3O3S
分子量407.49
MDL编号MFCD00117444

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
效能10 nM Ki
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 25 mg/mL
储存温度2-8℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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