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InSolution Glutaminase Inhibitor, Compound 968-Calbiochem

品牌
Sigma-Aldrich
货号
5.06073
包装型号
规格纯度
参考价格
1841.82 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10 µM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200 µg per inj. i.p., 12 days).

生化/生理作用

Cell permeable: yes
Reversible: yes
Primary Target
mitochondrial glutaminase

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

A 10 mM (5 mg/1.05 ml) sterile-filtered solution of Glutaminase Inhibitor, Compound 968 (Cat. No. 352010) in DMSO.

重悬

Following initial thaw slight warming may be required to resolubilize. Aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

其他说明

Wang, J.B., et al. 2010. Cancer Cell18, 207.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C27H27BrN2O
分子量475.42

产品性质

测定≥99% (HPLC)
质量水平100
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
储存温度−70℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)188.6 °F - (refers to pure substance)
闪点(C)87 ℃ - (refers to pure substance)

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