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Mitochondrial Pyruvate Carrier Inhibitor, UK5099-CAS 56396-35-1-Calbiochem

品牌
Sigma-Aldrich
CAS
56396-35-1
货号
5.04817
包装型号
规格纯度
参考价格
1339.54 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).

生化/生理作用

Cell permeable: yes
Primary Target
mitochondria
Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
Use only fresh DMSO for reconstitution.

其他说明

Divakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA110, 5422.
Bricker, D.K., et al. 2012. Science337, 96.
Herzig, S., et al. 2012. Science337, 93.
Hinoi, E., et al. 2006. Mol. Pharmacol.70, 925.
Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta1707, 221.
Halestrap, A.P. 1978. Biochem. J.172, 377.
Halestrap, A.P. 1975. Biochem. J.145, 85.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C18H12N2O2
分子量288.30
MDL编号MFCD19443867

产品性质

测定≥99% (HPLC)
质量水平100
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色bright yellow
溶解性DMSO: 100 mg/mL
储存温度2-8℃
InChI1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChI keyBIZNHCWFGNKBBZ-JLHYYAGUSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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