位置:首页 > 品牌 > Sigma-Aldrich >

(2-Hydroxypropyl)-β-cyclodextrin

(2-羟丙基)-β-环糊精

品牌
Sigma-Aldrich
CAS
128446-35-5
货号
389145
规格纯度
average Mw ~1,540
参考价格
440.69 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, is mainly used as a formulation vehicle to increase the dissolution of drugs in water for the successful delivery of medicinal agents to biological systems. It is commonly utilized as a substitute for α-, β- and γ-cyclodextrins.

应用

(2-Hydroxypropyl)-β-cyclodextrin may be used:

  • As an analytical standard for the determination of the analyte in pharmaceutical formulations as well as nanoparticle formulations by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC), respectively.
  • To study the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase HPLC technique.
  • As a mobile phase additive for the effective separation of β-carbolines by HPLC.
  • In cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) for the determination of sertraline hydrochloride and the synthesis-related products.
  • As a chiral selector to resolve pantothenic acid by capillary electrophoresis.

由于 HBC 和药物形成络合物,因此在水溶液中亲脂性药物的溶解度随着羟丙基-β-环糊精 (HBC) 的浓度线性增加。该客体-主体型络合物形成于药物和 HBC 的非极性腔之间,可引起增溶溶解。溶液可冻干生成易溶的粉末。对兔和小鼠无毒。

包装

5, 25 g in poly bottle

基本信息

EC 号420-920-1
PubChem化学物质编号24864264
NACRESNA.22

产品性质

质量水平100
旋光性[α]23/D +125°, c = 1 in H2O
分子量average Mw ~1,540
标记范围1.0 molar substitution dextrin
SMILES stringCC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
InChI1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1
InChI keyODLHGICHYURWBS-RYJYQAAZSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号