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p300 (C1135-2414) human

品牌
Sigma-Aldrich
货号
SRP2086
规格纯度
recombinant, expressed in insect cells, ≥70% (SDS-PAGE)
参考价格
7915.99 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

E1A binding protein p300 (p300) has a central bromodomain and three cysteine- and histidine-rich regions. The carboxy-terminal region interacts with the adenovirus oncoprotein E1A. The gene encoding this protein is localized on human chromosome 22q13.

生化/生理作用

Human p300 and CBP (CREB binding protein) are highly related transcriptional coactivators. Both proteins have been identified through protein interaction assays. In addition to interacting with a variety of cellular factors and onco-proteins, loss of the wild type CBP alleles in isolated tumors suggests that CBP/p300 might serve as a tumor suppressor. The C-terminus of p300 contains a histone acetyltransferase (HAT) domain expanded from residues 1195 to 1673, an activation domain (residues 1763-1812) that interacts with many transcription factors and an SRC-1 domain further down stream of the activation domain. P300 is able to acetylate histones and many other transcription factors, including p53, E2F, TFIIE, and TFIIF etc. implicating diverse roles of p300 in gene regulation.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in insect cells
测定≥70% (SDS-PAGE)
形式frozen liquid
分子量 ~145 kDa
包装pkg of 4 μg
浓度350 μg/mL
颜色clear colorless
NCBI登记号NM_001429
UniProt登记号Q09472
运输dry ice
储存温度−70℃
Gene Informationhuman ... EP300(2033)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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