位置:首页 > 品牌 > Sigma-Aldrich >

Anti-CLEC9A Antibody, clone 10B4

品牌
Sigma-Aldrich
货号
04-148
规格纯度
clone 10B4, from rat
参考价格
4513.21 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

CLEC9A, also known as Dendritic cell natural killer lectin group receptor 1 (DNGR-1), and encoded by the gene Clec9a/Dngr-1, functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the principal dendritic-cell subset involved in regulating cross-priming to cell-associated antigens. CLEC9A recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediates the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. CLEC9A is localized to the plasma membrane. CLEC9A is expressed in dendritic cells and has multiple isoforms; isoform 4 is expressed at high levels by CD8+ dendritic cells and at low levels by plasmacytoid DCs but not by other hematopoietic cells.

免疫原

KLH-conjugated linear peptide corresponding to mouse CLEC9A.

应用

Flow Cytometry Analysis: A representative lot from an independent laboratory detected CLEC9A in mouse Conventional Dendritic cells and on most Plasmacytoid Dendritic cells (Caminschi, I., et al. (2008). Blood. 112(8):3264-3273.).
Detect CLEC9A using this rat monoclonal antibody, Anti-CLEC9A Antibody, clone 10B4 validated for use in western blotting & Flow Cytometry.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

质量

Evaluated by Western Blotting in mouse lymph node tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected CLEC9A in 10 μg of mouse lymph node tissue lysate.

目标描述

~27 kDa and ~16 kDa observed. Uniprot describes five isoforms at 27 kDa, 27 kDa, 30 kDa, 20 kDa, and 17 kDa

外形

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源rat
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆10B4, monoclonal
species reactivitymouse
technique(s)flow cytometry: suitable
western blot: suitable
同位素/亚型IgG2aκ
NCBI登记号NP_001192292
UniProt登记号Q8BRU4
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号