产品说明
一般描述
Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. The localization and ubiquitous expression of this protein in neuronal tissue makes it an excellent marker for neurons and neuroendocrine tumors. The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.
特异性
This antibody reacts with presynaptic vesicles of cerebral and spinal neurons, of neuromuscular endplates and with the retina of man, cow, rat and mouse. It also reacts with vesicles of adrenal medulla and islet cells.
免疫原
Vesicular fraction of bovine brain
应用
Research Sub Category
Neuronal & Glial Markers
Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor 488 Conjugate detects level of Synaptophysin & has been published & validated for use in IH.
Research Category
Neuroscience
质量
Evaluated by Immunohistochemistry in adult mouse brain tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Synaptophysin in adult mouse brain tissue.
目标描述
The unconjugated parent antibody (Cat. No. MAB5258) has an observed molecular weight at ~38 kDa
外形
Protein G purified
Purified mouse monoclonal IgG1κ conjugated to Alexa Fluor® 488 in buffer containing 15 mg/ml BSA with 0.1% sodium azide.
储存及稳定性
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
分析说明
Control
Adult mouse brain tissue
其他说明
Uncongugated antibody (MAB5258) is shown to work on Rat.
法律信息
ALEXA FLUOR is a registered trademark of Life Technologies
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | ALEXA FLUOR® 488 |
| 抗体形式 | purified antibody |
| antibody product type | primary antibodies |
| 克隆 | SY38, monoclonal |
| species reactivity | mouse, human |
| species reactivity (predicted by homology) | bovine (immunogen homology) |
| technique(s) | immunohistochemistry: suitable |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | NP_776388 |
| UniProt登记号 | P20488 |
| 运输 | wet ice |
| Gene Information | human ... SYP(6855) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
