产品说明
一般描述
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
特异性
Broad species cross-reactivity is expected.
Histone H3 phosphorylated at Ser10
免疫原
Epitope: Ser10
A proprietary immunogen based on a peptide sequence containing phospho-serine corresponding to residue 10 of human histone H3.
应用
Anti-Phospho-Histone H3 (Ser10) Antibody, clone 3H10, Alexa Fluor® 488, is a Mouse Monoclonal Antibody for detection of Histone H3 phosphorylated at serine 10. This purified mAb, also known as H3S10p,
is labeled with Alexa Fluor
Research Category
Epigenetics & Nuclear Function
Apoptosis & Cancer
Research Sub Category
Histones
Cell Cycle, DNA Replication & Repair
质量
Evaluated by Flow Cytometry with Jurkat cells.
目标描述
17 kDa observed
外形
Purified mouse IgG1k conjugated to Alexa Fluor® 488 in PBS with 15mg/mL BSA and less than 0.09% sodium azide.
Protein G Purified
储存及稳定性
Maintain refrigerated at 2-8oC in undiluted aliquots for up to 6 months from date of receipt. Protect from light.
分析说明
Control
Jurkat Cells
法律信息
ALEXA FLUOR is a registered trademark of Life Technologies
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | ALEXA FLUOR® 488 |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 3H10, monoclonal |
| species reactivity | human |
| technique(s) | flow cytometry: suitable |
| 同位素/亚型 | IgG1κ |
| NCBI登记号 | NM_003493 |
| UniProt登记号 | Q16695 |
| 运输 | wet ice |
| Gene Information | human ... HIST1H3F(8968) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
