产品介绍：
产品说明
应用
Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) has been used as a:
- cathepsin inhibitor to study its effects on dendritic cells
- papain-like cysteine protease inhibitor to study its effects on cadmium-induced mitochondrial apoptosis
- cysteine protease inhibitor to study its effects on the interaction of toll-like receptor 9 (TLR9) with granulin in RAW macrophages
生化/生理作用
Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.
基本信息
| 线性分子式 | C21H23N2O4F |
| 分子量 | 386.42 |
| MDL编号 | MFCD00883668 |
| PubChem化学物质编号 | 329774889 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥90% (TLC) |
| 形式 | powder |
| 颜色 | white to off-white |
| 溶解性 | DMSO or DMF: 20 mM |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2)C(=O)CF |
| InChI | 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15-,18-/m0/s1 |
| InChI key | ASXVEBPEZMSPHB-YJBOKZPZSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
