产品说明
一般描述
TMD recognition complex of 40 kDa (TRC40) also known as arsA arsenite transporter, ATP-binding, homolog 1 (ASNA1), is encoded by the gene mapped to human chromosome 19p13.2. ASNA1 is the mammalian ortholog of yeast Arr4/Get3 gene. The encoded protein is abundantly expressed in pancreatic β cells.
ASNA1 is the human homolog of the bacterial arsA gene. In E. coli, ArsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials.
免疫原
ASNA1 (NP_004308, 239 a.a. ~ 348 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSAQ
生化/生理作用
Asna1/TRC40 interacts with the transmembrane domains (TMD) of newly released tail-anchored (TA) proteins and transfers them to the endoplasmic reticulum (ER) receptor for subsequent membrane insertion and thus, plays an essential role in TA protein biogenesis. The encoded protein is necessary for effective HSV1 replication. Asna1 acts as a key regulator of insulin signaling in C. elegans and mammalian cells.
特点和优势
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外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 2H3, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | mouse, rat, human |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable indirect ELISA: suitable indirect immunofluorescence: suitable western blot: 1-5 μg/mL |
| 同位素/亚型 | IgG1κ |
| GenBank® accession no. | NM_004317 |
| UniProt登记号 | O43681 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ASNA1(439) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
