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Valproic Acid, Sodium Salt-CAS 1069-66-5-Calbiochem

品牌
Sigma-Aldrich
CAS
1069-66-5
货号
676380
规格纯度
A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 μM for HDAC1).
参考价格
1090.74 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (0.35 mM - 1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates ERK pathway and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.

包装

5 g in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
HDAC1
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

其他说明

Gottlicher, M., et al. 2001. EMBO J.20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res.21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem.276, 31674.
Chen, G., et al. 1999. J. Neurochem.72, 1327.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C8H15NaO2
分子量166.19
MDL编号MFCD00078604
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
效能400 μM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性water: 50 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InChI keyAEQFSUDEHCCHBT-UHFFFAOYSA-M

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H302 - H361d
预防措施声明P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Repr. 2
储存分类代码11 - Combustible Solids
WGKWGK 3

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