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Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse

抗-表皮生长因子受体单克隆抗体 小鼠抗

品牌
Sigma-Aldrich
货号
E3138
规格纯度
clone F4, ascites fluid
参考价格
1794.63 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Monoclonal Anti-Epidermal Growth Factor (EGF) Receptor (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The receptor for epidermal growth factor is an integral cell membrane protein of 170 kD, which spans the membranes of a wide range of normal and malignant epithelial cells. EGF-R have been identified in sarcomas, gliomas, breast, bladder, lung and gynecological tumors. The EGF-R has a half-life of approximately 10 hours in human fibroblasts, but in the presence of EGF this value is reduced to about 1 hour.

特异性

This antibody recognizes specifically an intracellular domain of the EGF receptor.

免疫原

synthetically produced residues 985-996 of the human EGF receptor.

应用

Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse has been used in:

  • western blotting
  • immunoprecipitation
  • immunocytochemistry
  • immunohistochemical staining

生化/生理作用

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer.
Epidermal growth factor receptor (EGF-R) is a tyrosine-specific protein kinase with the capacity to phosphorylate tyrosine residues located near its carboxy-terminus.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00162282
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式ascites fluid
antibody product typeprimary antibodies
克隆F4, monoclonal
包含15 mM sodium azide
species reactivityhuman
包装antibody small pack of 25 μL
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:2,000
同位素/亚型IgG1
UniProt登记号P00533
运输dry ice
储存温度−20℃
Gene Informationhuman ... EGFR(1956)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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